Sunday, June 3, 2012

Straightforward Personal Development Recommendations That ...

The notion of personal development has become a lot more personal-informed and fruitful. Satisfying private goals, getting personal understanding and working on your spirituality are all important for personal development. This article touches on a lot of different tips on how to work on self improvement. Through taking it little by little you will know who you are.

Lots of people use a self improvement aim that may be also hazy, and therefore tough to evaluate. Be sure to come up with a target aim for your self. The greater certain the aim, the better distinct the results you are going to attain.

Have a modest standpoint. Everybody is just a little section of the world. Everyone offers quite a bit to learn from all the others. Bear this in mind, and you will have unlimited prospect of growth. Simply being open-minded as to what other people can instruct us is the best way to increase.

Enhancing your overall health is an important element of self improvement. Developing a healthy life-style requires anyone to stay motivated at all times. When it?s essential that you should remain healthy and you do so, you are going to feel good also it can help improve other areas of your way of life.

The first step in shifting is making a decision to modify. If we wish to develop or modify, we will need to take and judge the change.

Look after oneself actually to have the most out of your own advancement actions. Place yourself on the way to achievement with self improvement simply by making certain your fundamental will need are satisfied, which include sufficient quantities of rest, nourishing foods and a normal exercise regimen. Even though it may seem simple, this is certainly sometimes one of the most difficult things to do.

You should always strive to be the best in your neighborhood. Allow your hobbies direct you. The simple fact of the subject is we are never the best at every very little issue, but we can be considered an excellent motivation to numerous in our particular field. Boost your ranking in your niche market, plus your confidence will climb too.

They are saying that communicating and paying attention are essential. This really is when bettering yourself. Make sure you are taking time to listen to oneself. Should you don?t, you won?t understand your requirements and that may make better yourself extremely difficult.

When commencing your own advancement plan, set up achievable goals for that temporary and long term. Switching your viewpoint about the future is centered on your perspective into it. For those who have long term objectives to agree to and enjoy, you will discover on your own in a more beneficial state of mind.

Use your central guidelines to help you when you start to act. Every individual has beliefs that provide their central feeling of self. In case you have an excellent groundwork to protect them upon (and you need to), your self esteem will manage to benefit from adherence to the key principles. Much better, this training stimulates consistency, which is a great figure attribute to keep.

So that you can grow like a man or woman, you have to give your way of life direction. Long term objectives really are a huge thing to possess and can create a significant difference inside your standpoint.

To make any type of progress making use of the report you may have just gone more than, you?re planning to must apply the info. Without having the effort on your part, success will likely be evasive. Apply the tips from this write-up for your daily life, and you should see some advancement in your community of the personal development.

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Saturday, June 2, 2012

Sanam Lyonpo meets with Bangladesh Business Delegation- Minutes

The 22 member FBCCI business delegation with MoAF Minister, Lyonpo (Dr.) Pema Gyamtsho

A 22 member Federation of Bangladesh Chambers of Commerce and Industry (FBCCI) business delegation from Bangladesh led by Mr. A.K. Azad called on the Hon?ble Sanam Lyonpo on 31 May 2012 at the MoAF Conference Hall at 11 am. After the pleasantries and opening remarks by Sanam Lyonpo on the excellent relationship between Bangladesh and Bhutan at all levels and after further remarks by His Excellency, the Ambassador of Bangladesh to Bhutan on the increase of trade and commerce, the following were discussed:

  1. The need to take advantage of the strengths and opportunities that exist between the two countries to promote trade links
  2. The need to work closely in forest and water sector; Bhutan has high value timbers for furniture and clean water resources to venture into bottled water
  3. Bird watchers, butterfly lovers etc could have exchange programmes within the framework of the Eastern Himalayas Conference on Climate Change as birds are good indicators of climate change.
  4. The meeting agreed that there are prospects for business venture in agriculture and agri business? through FDI and contact farming. Prospects? exists ?in? seed potato, ginger, cardamom, garlic, turmeric, asparagus, high value vegetables and in agro processing sector including mineral water.
  5. It was agreed that there is scope to increase volume and value of the presently traded goods in agriculture especially fruits and summer vegetables.
  6. Prospects in establishing furniture? houses under FDI arrangements was also discussed and agreed to be pursued through EPZ or industrial zone model where Bangladeshi investors could invest or impart their technical know how.
  7. After a price comparative study and a rapid market appraisal, the prospects of importing meat and fish items from Bangladesh should be pursued.
  8. It was noted that Bangladesh has many cold storage facilities in Rangpur area which is just over 200 kms from Phuentsholing. The delegates from Bangladesh offered to? help and impart their technical know how should Bhutan wish to? develop cold storage chain in Bhutan.
  9. The Department of Agricultural Marketing and Cooperatives will follow up on all the matters that has been discussed during this meeting. The department has been directed to send samples of seed potato and turmeric.

10. The Bangladesh Delegation extended an invitation to His Excellency the Sanam Lyonpo to visit Bangladesh with a delegation from the agricultural sector.? The delegation express their hope to receive His Excellency in Bangladesh during which time visits could be made to cold storage facilities, the furniture houses, fish and meat processing plants, Export Processing Zones and the sea port at Chittagong.

The meeting ended with exchange of pleasantries at 1140 hrs.

June 1, 2012 ??admin Posted?in:?News 75 views


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NATO: 4 aid workers rescued from Afghan insurgents

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Friday, June 1, 2012

New therapy on the horizon for ALK+ non-small cell lung cancer

New therapy on the horizon for ALK+ non-small cell lung cancer [ Back to EurekAlert! ] Public release date: 1-Jun-2012
[ | E-mail | Share Share ]

Contact: Diana Quattrone
diana.quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center

CHICAGO, IL (June 1, 2012)A new compound that targets anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer is well-tolerated by patients and is already showing early signs of activity, including in patients who no longer respond to crizotinibthe only approved ALK inhibitor. Results of this Novartis-sponsored sudy will be presented by a researcher from Fox Chase Cancer Center during the 2012 Annual Meeting of the American Society of Clinical Oncology on Sunday, June 3.

The compound LDK378, developed by Novartis, targets ALKa key cancer gene in a subset of lung cancer, lymphoma and the childhood cancer neuroblastoma, and may be associated with other cancers, including breast and colorectal cancer. The study's authors looked at patients with ALK+ lung cancer, as well as other ALK+ solid tumors. Early data from the phase I study show that the majority of patients treated with active doses of LDK378 responded, including those who had progressed after treatment with crizotinib.

"These results are encouraging," says study author Ranee Mehra, M.D., assistant professor and medical oncologist at Fox Chase. "They offer hope to patients who have tumors with alterations involving ALK, even if they have relapsed from previous treatments.

In its first test in people, designed to determine the compound's safety and optimal dose, 56 people with various types of ALK+ solid tumors (primarily lung cancer) were enrolled, receiving doses between 50 to 750 milligrams per day (mg/day). LDK378 was well-tolerated in most patients up to 750 mg/d, with the most common side effects being nausea, vomiting, and diarrhea.

"Whenever you do a trial with a drug, even if it's just designed to look for safety and dosage, you are interested in whether patients responded," says Mehra. "These results are definitely encouraging, and mean we can go forward with additional research looking at whether LDK378 is effective in various types of cancers that have alterations involving ALK."

The fact that patients appeared to tolerate LDK378 at doses up to 750 mg/d is also encouraging, she adds, since preclinical research has suggested this dose would have therapeutic effects.

In the meantime, Mehra and investigators at other centers around the world are continuing to enroll patients in the trial. The next phase of the study will test the maximum tolerated dose of LDK378 in all patients enrolled.

###

This study was sponsored and funded by Novartis.

Mehra's co-authors include: Mehra's co-authors include: [D. Ross Camidge (University of Colorado, Denver, CO), Sunil Sharma (Huntsman Cancer Center, Salt Lake City, UT), Enriqueta Felip (Vall d'Hebron University Hospital, Barcelona, Spain), Daniel Shao-Weng Tan (National Cancer Centre, Singapore, Singapore), Johan F. Vansteenkiste (University Hospital Gasthuisberg, Leuven, Belgium), Tommaso Martino De Pas (European Institute of Oncology, Milan, Italy), Dong-Wan Kim (Seoul National University Hospital, Seoul, South Korea), Armando Santoro (Humanitas Cancer Center, Rozzano, Italy), Geoffrey Liu (Princess Margaret Hospital, Toronto, ON), Meredith Goldwasser (Novartis Institutes for BioMedical Research, Cambridge, MA), David Dai (Novartis Pharmaceuticals, East Hanover, NJ), Marietta Radona (Novartis Pharmaceuticals, East Hanover, NJ), Anthony Boral (Novartis Institutes for BioMedical Research, Cambridge, MA), Alice Tsang Shaw (Massachusetts General Hospital Cancer Center, Boston, MA).

Fox Chase Cancer Center is one of the leading cancer research and treatment centers in the United States. Founded in 1904 in Philadelphia as one of the nation's first cancer hospitals, Fox Chase was also among the first institutions to be designated a National Cancer Institute Comprehensive Cancer Center in 1974. Fox Chase researchers have won the highest awards in their fields, including two Nobel Prizes. Fox Chase physicians are also routinely recognized in national rankings, and the Center's nursing program has received the Magnet status for excellence three consecutive times. Today, Fox Chase conducts a broad array of nationally competitive basic, translational, and clinical research, with special programs in cancer prevention, detection, survivorship, and community outreach. For more information, visit Fox Chase's Web site at www.foxchase.org or call 1-888-FOX CHASE or (1-888-369-2427).


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New therapy on the horizon for ALK+ non-small cell lung cancer [ Back to EurekAlert! ] Public release date: 1-Jun-2012
[ | E-mail | Share Share ]

Contact: Diana Quattrone
diana.quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center

CHICAGO, IL (June 1, 2012)A new compound that targets anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer is well-tolerated by patients and is already showing early signs of activity, including in patients who no longer respond to crizotinibthe only approved ALK inhibitor. Results of this Novartis-sponsored sudy will be presented by a researcher from Fox Chase Cancer Center during the 2012 Annual Meeting of the American Society of Clinical Oncology on Sunday, June 3.

The compound LDK378, developed by Novartis, targets ALKa key cancer gene in a subset of lung cancer, lymphoma and the childhood cancer neuroblastoma, and may be associated with other cancers, including breast and colorectal cancer. The study's authors looked at patients with ALK+ lung cancer, as well as other ALK+ solid tumors. Early data from the phase I study show that the majority of patients treated with active doses of LDK378 responded, including those who had progressed after treatment with crizotinib.

"These results are encouraging," says study author Ranee Mehra, M.D., assistant professor and medical oncologist at Fox Chase. "They offer hope to patients who have tumors with alterations involving ALK, even if they have relapsed from previous treatments.

In its first test in people, designed to determine the compound's safety and optimal dose, 56 people with various types of ALK+ solid tumors (primarily lung cancer) were enrolled, receiving doses between 50 to 750 milligrams per day (mg/day). LDK378 was well-tolerated in most patients up to 750 mg/d, with the most common side effects being nausea, vomiting, and diarrhea.

"Whenever you do a trial with a drug, even if it's just designed to look for safety and dosage, you are interested in whether patients responded," says Mehra. "These results are definitely encouraging, and mean we can go forward with additional research looking at whether LDK378 is effective in various types of cancers that have alterations involving ALK."

The fact that patients appeared to tolerate LDK378 at doses up to 750 mg/d is also encouraging, she adds, since preclinical research has suggested this dose would have therapeutic effects.

In the meantime, Mehra and investigators at other centers around the world are continuing to enroll patients in the trial. The next phase of the study will test the maximum tolerated dose of LDK378 in all patients enrolled.

###

This study was sponsored and funded by Novartis.

Mehra's co-authors include: Mehra's co-authors include: [D. Ross Camidge (University of Colorado, Denver, CO), Sunil Sharma (Huntsman Cancer Center, Salt Lake City, UT), Enriqueta Felip (Vall d'Hebron University Hospital, Barcelona, Spain), Daniel Shao-Weng Tan (National Cancer Centre, Singapore, Singapore), Johan F. Vansteenkiste (University Hospital Gasthuisberg, Leuven, Belgium), Tommaso Martino De Pas (European Institute of Oncology, Milan, Italy), Dong-Wan Kim (Seoul National University Hospital, Seoul, South Korea), Armando Santoro (Humanitas Cancer Center, Rozzano, Italy), Geoffrey Liu (Princess Margaret Hospital, Toronto, ON), Meredith Goldwasser (Novartis Institutes for BioMedical Research, Cambridge, MA), David Dai (Novartis Pharmaceuticals, East Hanover, NJ), Marietta Radona (Novartis Pharmaceuticals, East Hanover, NJ), Anthony Boral (Novartis Institutes for BioMedical Research, Cambridge, MA), Alice Tsang Shaw (Massachusetts General Hospital Cancer Center, Boston, MA).

Fox Chase Cancer Center is one of the leading cancer research and treatment centers in the United States. Founded in 1904 in Philadelphia as one of the nation's first cancer hospitals, Fox Chase was also among the first institutions to be designated a National Cancer Institute Comprehensive Cancer Center in 1974. Fox Chase researchers have won the highest awards in their fields, including two Nobel Prizes. Fox Chase physicians are also routinely recognized in national rankings, and the Center's nursing program has received the Magnet status for excellence three consecutive times. Today, Fox Chase conducts a broad array of nationally competitive basic, translational, and clinical research, with special programs in cancer prevention, detection, survivorship, and community outreach. For more information, visit Fox Chase's Web site at www.foxchase.org or call 1-888-FOX CHASE or (1-888-369-2427).


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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Romanian mining town suffers from its gold riches

ROSIA MONTANA, Romania (Reuters) - Nature has carved a humbling landscape of deep river valleys and reddish peaks in a corner of the Carpathian mountains in western Romania.

Rosia Montana town, made up of 16 villages that dot the slopes along the river Rosia, has hundred-year-old churches and houses, cemeteries and ancient Roman mine galleries.

It also has gold. But for those who live here, that is more of a bane than anything else.

Canada's Gabriel Resources wants to build Europe's largest open cast gold mine in Rosia Montana, a 15-year quest that has put the area at the centre of a national debate between heritage and development.

The mine could bring billions of euros in taxes and potentially thousands of jobs to an economically depressed region. But it will also require blasting four mountain tops, relocating the community and flooding one village to create a 300-hectare pond for chemical waste held back by a 180-metre-high dam.

The mine has the support of most of the 2,800 locals, the mayor and county administration and President Traian Basescu, eyeing the bounty the investment will bring.

Those who oppose the project - a handful of residents, several church, environmental and human rights groups, the Soros Foundation and neighbor Hungary, which fears the consequences of any environmental damage - want to turn the area into a UNESCO heritage site focused on tourism and farming.

Critics are concerned that concession rights were awarded without transparency and without exploring other options.

Romania's new leftist Prime Minister Victor Ponta, a political opponent of Basescu, has openly criticized both the plan and the president's support, and the topic will be a focus of debate in the run-up to a November parliamentary election.

The issue also cuts to the heart of Romania's economic problems, as the European Union's second-poorest nation struggles to take advantage of its resources and strategic location between western Europe and the Middle East.

"Basically it's a choice between two world views set around the question of how we see Rosia Montana and Romania's future in five, 50 or 500 years," said Magor Csibi, country manager at the Romanian arm of environmental group WWF.

"It's a war of nerves," said Csibi. "Whoever lasts longest wins."

TWO SIDES TO THE STORY

When hundreds rally against the mine in the capital Bucharest, hundreds rally in Rosia Montana in support. When Greenpeace activists stormed the ministry chaining themselves to radiators in January, mine supporters gathered outside demanding jobs days later. Countless court cases challenging the permits are pending, as are many appeals by the company.

Stuck in the middle, with no other source of employment, the community is slowly dying out. The villages lack central heating or running water and infrastructure is decaying, while previous mines have polluted the water.

Most locals hope Gabriel Resources' Romanian unit, Rosia Montana Gold Corporation (RMGC), will restore jobs and the economy.

In fact, mining is the reason there is a community here at all.

The town is in the Golden Quadrilateral, an area of about 900 sq km (350 sq miles) which holds one of Europe's largest gold reserves and is also rich in copper and silver.

The town was founded on mining before Roman times and enriched waves of foreigners who moved to the area under Austro-Hungarian rule.

Nelu Oprisa grew up here and spent 17 years at the state gold mine, working his way up to chief engineer by the time it closed and he retired. He sold his property to RMGC in 2003 and moved to a nearby town, although he still comes back often to look after to a private tourist organization.

"There used to be a time when Rosia was not necessarily thriving, but people had a routine, they worked hard at the mine ... drank a little brandy and went home," said the 52-year-old, smoking and sipping coffee on the main square.

"People had jobs. And we were a lot closer to each other."

But after the 1989 collapse of communism, Romania was left with an inefficient, heavily subsidized mining sector that employed hundreds of thousands and scarred the environment. It closed hundreds of mines and sacked workers. The government estimates it still needs 1 billion euros ($1.2 billion) for ecological repairs.

Many people left Rosia Montana. Others, like Oprisa, sold their properties to RMGC and moved to modern houses the firm built in the town of Alba Iulia, 80 km (50 miles) away.

"The Romanian state cannot sit on the largest gold reserve in Europe without investing," Oprisa said.

Eugen David, a former copper miner who moved to Rosia Montana roughly 17 years ago when he met his wife, feels differently. He owns land on top of one of RMGC's planned quarries and where it aims to build a processing plant and says he will give it up only by force.

As the head of anti-mine organization Alburnus Maior, David no longer greets the mayor or Oprisa. His alternative to the mine is farming and using Rosia Montana's notoriety to attract tourists.

"I have a fundamental right to live here," the charismatic 47-year-old said in his backyard, where he and his family run a cattle farm. "I never understood why mining is hailed as the sole development solution for this place. I mean, we haven't developed much in 2,000 years of mining."

Several thousand people visit Rosia Montana each year, most just passing through. Even with massive investment, there is little guarantee the locals will be able to earn enough from tourism.

At the moment, it is difficult to get to and has little tourism infrastructure in spite of its natural beauty and mining heritage.

"If it goes forward it will destroy this community. There will be no more mountains. The company will relocate 1,000 families. How is that good for the community?" David said.

"Not everybody will earn a living from the mine, just as not everybody will earn a living from tourism and farming. But these would be cleaner, more sustainable jobs."

EUROPE'S BIGGEST GOLD MINE

RMGC, in which the Romanian state holds a 19-percent stake, started exploration work in Rosia Montana in 1997 and secured concession rights two years later. Opponents are angry that parts of the agreement are confidential under the country's natural resources legislation, while the project has discouraged any other potential investment.

RMGC estimated the mine is worth $7.5 billion overall and that the state would get more than half of that in royalties, taxes, dividends and indirect services, based on a 2007 study that used an average price of $900 per gold ounce. The economy ministry approved the study without conducting an independent survey.

Gabriel's CEO says the mine could be worth roughly $30 billion at current prices of roughly $1,600 per ounce, and the mine would make Romania the EU's largest gold producer, overtaking Finland, Sweden and Spain.

RMGC plans to dig four quarries on mountain tops, where open pits are necessary to extract the gold and silver particles embedded in the rock, and four of the 16 villages will be largely destroyed.

Cyanide will be used to separate the metals, and the waste treated, then stored in a mud pond where the concentration will be reduced to 5-7 milligrams, below the EU's legal limit.

The pond, one of the most contested issues in the project, would wipe out Corna village. This patch of chemical waste will be contained by a dam the company says can withstand massive earthquakes and rainfall.

Memories of the potential for broken dam disasters are fresh after Hungary's 2010 red sludge spill. Romania has a poor track record of its own after a dam broke in 2000 at a gold processing plant and cyanide poured into the river Tisza, affecting much of eastern Europe, including Hungary.

RMGC says it will use the safest, most up-to-date technology and plans to fix environmental damage, plant trees, completely restore the old centre and create a vast gold mining museum.

"We have addressed all the concerns related to the project and we would like the approval process to go on," said RMGC director Dragos Tanase. "Miners are not looking for favors, but it is also not fair to block important investment for years."

POLITICAL GAME

The project has become a political hot potato after 15 years mired in Romania's bureaucratic process. An environmental permit has still not been issued and a final decision looks distant.

It has a powerful backer in Basescu, who for more than a year has used almost every public appearance to urge politicians to support mining to create jobs and boost the economy.

His comments have often sparked small protests across the country and have drawn criticism from the new prime minister, Ponta, who before he came to power pledged to block the plan.

"Projects of this magnitude cannot be made simply because a politician really wants it, regardless of his name. I obviously mean President Basescu," Ponta said.

He and Environment Minister Rovana Plumb, who has said Romania should reject cyanide mining on principle, have softened their rhetoric since coming to power in early May.

But the November election could cause more delays. Even if RMGC gets the environment permit, the opposition will challenge the decision in courts.

Meanwhile, Rosia Montana remains in limbo. According to Mayor Eugen Furdui, RMGC already employs some 500 people and has helped halve the unemployment rate - but it is still at 40 percent.

"Politicians seem forever shy about making a decision either way, and that is perhaps what hurts Rosia Montana the most," said Oprisa.

(Editing by Sonya Hepinstall)

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Authors win class status over Google books

(Reuters) - Thousands of authors can sue Google Inc in a class-action lawsuit over its plan to create the world's largest digital book library, a federal judge ruled on Thursday.

U.S. Circuit Judge Denny Chin in Manhattan also rejected Google's bid to dismiss claims by The Authors Guild and several groups representing photographers and graphic artists, which would have forced their members to sue individually.

Plaintiffs in the seven-year-old case have complained that Google's plan for the library, which would include millions of out-of-print works, amounted to "massive copyright infringement."

The case arose from Google's 2004 agreement with several big research libraries to digitally copy books and other writings for its Google Books website, with a goal of helping researchers and the general public locate the materials.

Google has since scanned more than 12 million books, but planned to provide only snippets online, saying this activity constituted "fair use" under U.S. copyright law.

Chin said it would be more efficient for authors to sue as a group, rather than risk disparate results and the "exponentially" higher costs of individual lawsuits.

He also said it would be unjust to force members of The Authors Guild, the American Society of Media Photographers and other groups to sue individually "given the sweeping and undiscriminating nature of Google's unauthorized copying."

The litigation combines lawsuits against Mountain View, California-based Google in 2005 on behalf of authors, and in 2010 on behalf of photographers and graphic artists.

A Google spokeswoman said in an emailed statement: "As we've said all along, we are confident that Google Books is fully compliant with copyright law."

Lawyers for the plaintiffs did not immediately respond to requests for comment.

In March 2011, Chin cited antitrust and copyright concerns in rejecting a proposed comprehensive $125 million settlement, saying it went "too far" in letting Google effectively conduct "wholesale copying of copyrighted works without permission."

Chin was elevated in 2010 to the federal appeals court in New York, but kept jurisdiction over the Google case, which he had begun overseeing as a trial judge.

The cases are The Authors Guild et al v. Google Inc, U.S. District Court, Southern District of New York, No. 05-08136; and American Society of Media Photographers et al v. Google Inc in the same court, No. 10-02977.

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